I used to play flag football year-round when I was down in Charleston. It was a great league with over 35 teams split into divisions. Now that I'm here and most of my evenings in the fall are spent coaching, I just don't have the time anymore to do that. The closest league is in Greenville, and that's about an hour long drive. I may play next spring, because I miss it.
I do still play basketball in the winter in a men's league. I've been asked to play softball a few times, but I'm not really interested.
Right now, I'm playing in an adult kickball league and it's freaking awesome. Teams are allowed to bring beer out to the games and it's a good time. It gets way more competitive than kickball should, but it's a great way to spend time and meet people from the area.