Paul Ryan spoke on her behalf when she ran for circuit Court of whatever the freak.
So do I think if he did so again, could it get her a single vote two or three? I'd imagine so
Her husband is irrelevant
I don't think "the right" will support her, but she only needs a handful
I think Murkowski and Collins vote for any realistic SC nominee. I think Manchin does too, for that matter. I'm completely out of my depth predicting what Sinema will ever do. No other Dem will realistically vote against a Biden nominee. I don't think being Paul Ryan's n-law will really play into it one way or another, except as vague reassurance that she's part of the in-crowd in terms of national politics.